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James Stein Interview with SAMSON senior author Darrel Francis: Statin Side Effects – The Symptoms are Real

James Stein Interview with SAMSON senior author Darrel Francis: Statin Side Effects – The Symptoms are Real

The SAMSON trial recruited patients who had given up statins for good due to side effects. Why was the trial needed and what do the…

SAMSON and the Future of Clinical Trials in Cardiology

The most interesting and impactful trial presented at the AHA this week (and simultaneously published in the New England Journal of Medicine) was the SAMSON trial,…

Cardiology Research: Business As Usual During the Pandemic

The middle of a raging pandemic is no time for business-as-usual research studies, especially when the studies falsely purport to shed light on that pandemic. Such papers have all the appearance of high quality science. They have a ton of data and a lot of big words but they’re incapable of providing reliable or useful information that can aid in our understanding and control of the health emergency.

COVID-19 Heart: We have all the gear but no idea

We have plenty of sophisticated gear to understand heart problems. For COVID-19, we’ve seen Troponin blood tests, cardiac MRIs and echo. For example, cardiac injury was associated with a higher risk of death in hospitalized patients. And yet, we have no answers to the questions that matter for clinical practice.

Darrel Francis Interview with Matthew Budoff: Demistifying the EVAPORATE trial of icosapent ethyl

Darrel Francis speaks to Matthew Budoff about EVAPORATE trial and asks about the plaque progression in the placebo arm and the choice of placebo. EVAPORATE was a follow-on mechanistic study from REDUCE-IT and was presented at the European Society of Cardiology 2020 and published in the European Heart Journal.

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Mission statement

CVCT CardioBrief will provide a platform for a diverse spectrum of opinions and perspectives on issues of interest to the cardiovascular clinical trials community. We aim to promote rigorous, unbiased, and patient-centred scientific discourse and debate within the cardiovascular community. CVCT CardioBrief does not seek to compete with medical journals or other traditional forums; instead we seek to create an accessible and responsive forum for discussion about important cardiovascular trials and other significant developments. It is our goal to provide a voice for perspectives that may not have always been able to gain exposure and consideration in traditional settings.

CVCT CardioBrief is an expansion of the CardioBrief website and is published by the CVCT Forum.

Would you like to write for CVCT CardioBrief? We are looking for brief original contributions of interest to the broad cardiovascular clinical trial community. We also invite readers to respond to posts and take part in the discussion on the site. Please send inquries or submissions to