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Thoughts about the use of the Win Ratio in Cardiovascular Outcome Trials

Cardiovascular trials often include non-fatal events (in addition to mortality) in their primary endpoints maintain the study power i.e., to capture enough events to detect…

A Pragmatic Trial isn’t just a Simple Trial: An Interview with Colin Baigent about ADAPTABLE

Faiez Zannad speaks to Colin Baigent about pragmatic randomised trials following his editorial on ADAPTABLE.

Speculations on PARADISE-MI (sacubitril/valsartan post-MI) before the full results

Marc Pfeffer presented the results of PARADISE-MI at ACC last week. As discussed previously on CVCTCardiobrief, sacubitril/valsartan did not reduce the primary outcome compared to…

Wishful Thinking About Revascularization for Stable Coronary Artery Disease

A new meta-analysis concludes that revascularization for stable coronary artery disease has benefits over and above the benefits of medical therapy. But this may be wishful thinking.

LAA Closure During Heart Surgery – A Robust Positive Trial But What’s Next?

Richard Whitlock MD, PhD of McMaster University in Hamilton, Ontario presented the outcomes of the LAAOS III trial as a late breaking clinical trial (LBCT)…

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Mission statement

CVCT CardioBrief will provide a platform for a diverse spectrum of opinions and perspectives on issues of interest to the cardiovascular clinical trials community. We aim to promote rigorous, unbiased, and patient-centred scientific discourse and debate within the cardiovascular community. CVCT CardioBrief does not seek to compete with medical journals or other traditional forums; instead we seek to create an accessible and responsive forum for discussion about important cardiovascular trials and other significant developments. It is our goal to provide a voice for perspectives that may not have always been able to gain exposure and consideration in traditional settings.

CVCT CardioBrief is an expansion of the CardioBrief website and is published by the CVCT Forum.

Would you like to write for CVCT CardioBrief? We are looking for brief original contributions of interest to the broad cardiovascular clinical trial community. We also invite readers to respond to posts and take part in the discussion on the site. Please send inquries or submissions to