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May 26, 20212021-05-26T06:58:17-04:00

Speculations on PARADISE-MI (sacubitril/valsartan post-MI) before the full results

By : Alexandra Nowbar

Marc Pfeffer presented the results of PARADISE-MI at ACC last week. As discussed previously on CVCTCardiobrief, sacubitril/valsartan did not reduce the primary outcome compared to…

April 04, 2016

ATMOSPHERE: Heart Failure Trial Poisoned By Controversy

By : Larry Husten

–Aliskiren raised regulatory pandemonium as it crashed in trials When it comes to interrupting the renin-angiotensin system, the third time was definitely not the charm.…

January 28, 2013

Study Warns Against Dual Blockade of Renin-Angiotensin System In Heart Failure And Hypertension

By : Larry Husten

The enormous success of ACE inhibitors in hypertension and heart failure spurred hope that adding a second drug to block the renin-angiotensin system would yield…

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