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November 28, 20202020-11-28T06:33:49-05:00

CVCT Forum 2020 Teaser: Darrel Francis interview with Faiez Zannad on Meta-Analysis Interpretation

By : Alexandra Nowbar and Darrel Francis

Darrel Francis speaks to Faiez Zannad about his meta-analysis of SGLT2 inhibitors for heart failure with reduced ejection fraction published inThe Lancet. This interview takes you through the key components of the meta-analysis: Forest plots, what to make of the heterogeneity of effect, and subgroup analyses.

November 17, 2020

SAMSON and the Future of Clinical Trials in Cardiology

By : Larry Husten

The most interesting and impactful trial presented at the AHA this week (and simultaneously published in the New England Journal of Medicine) was the SAMSON trial,…

October 21, 20202020-10-23T10:18:07-04:00

CVCT Global Forum Preview: One Patient Does Not Engagement Make

By : Penilla Gunther

What is “patient engagement”? What does that really mean, and how can we ensure that patients are given opportunities to provide meaningful input into clinical trials?

August 21, 20202020-08-29T13:11:29-04:00

Challenges in Minorities’ Participation in Clinical Trials: Feedback from the Participants

By : Wanda F Moore

The minority population was 38% of the total U.S. population in 2014 and is expected to rise to 56% by 2060. Although minorities make up…

August 06, 20202020-08-06T13:42:57-04:00

COVID-19 Lessons: How can we learn from our mistakes? What trials should we do?

By : Thomas Deering

Background The worldwide growth in coronavirus infections, followed by the WHO declaration of a global pandemic, led patients and government officials everywhere, concerned about serious…

July 24, 20202020-08-29T13:15:08-04:00

Learning Amidst A Pandemic: Collecting COVID-19 Data Across Cardiovascular Clinical Trials

By : Ankeet Bhatt

In December 2019, the rumblings of a virus meandering its way through Wuhan province in China slowly made their way to Western airways. Little attention…

March 30, 20182018-03-30T13:23:18-04:00

More Controversy Over Major Cardiology Clinical Trial

By : Larry Husten

Think about this: A new article reports that a major NIH-funded trial runs into trouble. The article raises all sorts of fundamental questions about our…

March 18, 20182018-03-30T13:22:10-04:00

Cardiology World Erupts Into Controversy Over Change In Major Clinical Trial

By : Larry Husten

As a major clinical trial in cardiology nears completion it has provoked a storm of criticism and controversy. The brouhaha erupted in response to a…

Moment Of Truth For Struggling And Expensive Cholesterol Drugs
February 15, 2018

Moment Of Truth For Struggling And Expensive Cholesterol Drugs

By : Larry Husten

It will be the moment of truth for the expensive new cholesterol drugs known as PCSK9 inhibitors. Next month we will learn much more about…

December 06, 2017

Clinical Trials: You Can’t Always Get What You Want

By : Larry Husten

–Trial investigators have lost control of their trials’ messages. Editor’s Note: The following is a lightly edited version of a talk I presented (without slides!)…

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