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Faiez Zannad speaks to Colin Baigent about pragmatic randomised trials following his editorial on ADAPTABLE.
High Rate of Crossovers in ADAPTABLE Aspirin Dosing Trial
Until now the optimal dosing of aspirin in terms of efficacy and safety for secondary prevention of atherosclerotic cardiovascular disease had not been previously well…
The First Truly Effective Weight Loss Drug Arrives
It looks like the first truly effective weight loss drug has arrived. Learn the basic facts about semaglutide and get perspectives from Milton Packer and Sanjay Kaul on what lies ahead.
A Schooling in Side Effects
The other day, I had the pleasure of being corrected by ever-impressive Milton Packer and I feel obliged to share his teachings with you. The…
Trials in Heart Failure with Preserved Ejection Fraction: An Interview with Steve Nissen and Milton Packer
Faiez Zannad moderates a fascinating discussion between Milton Packer and Steve Nissen about the PARAGON-HF trial in heart failure with preserved ejection fraction. Nissen was…
Salt Intake, Life Expectancy and Mortality: A Not-So-Salty Story for the Holidays
Numerous publications attest to the observation that a high salt intake can trigger hypertensive cardiovascular disease de novo or accelerate pre-existing hypertension. For decades practicing physicians have warned their patients about excessive salt intake.
CVCT Forum 2020 Teaser: Darrel Francis interview with Faiez Zannad on Meta-Analysis Interpretation
Darrel Francis speaks to Faiez Zannad about his meta-analysis of SGLT2 inhibitors for heart failure with reduced ejection fraction published inThe Lancet. This interview takes you through the key components of the meta-analysis: Forest plots, what to make of the heterogeneity of effect, and subgroup analyses.
James Stein Interview with SAMSON senior author Darrel Francis: Statin Side Effects – The Symptoms are Real
The SAMSON trial recruited patients who had given up statins for good due to side effects. Why was the trial needed and what do the…
SAMSON and the Future of Clinical Trials in Cardiology
The most interesting and impactful trial presented at the AHA this week (and simultaneously published in the New England Journal of Medicine) was the SAMSON trial,…