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Cardiovascular trials often include non-fatal events (in addition to mortality) in their primary endpoints maintain the study power i.e., to capture enough events to detect…
Speculations on PARADISE-MI (sacubitril/valsartan post-MI) before the full results
Marc Pfeffer presented the results of PARADISE-MI at ACC last week. As discussed previously on CVCTCardiobrief, sacubitril/valsartan did not reduce the primary outcome compared to…
Meet Spironolactone and Eplerenone’s Cardio-kidney Cousin, Finerenone
Spironolactone and eplerenone improve outcomes in heart failure. Finerenone is the newest mineralocorticoid receptor antagonist and is being tested for treatment of chronic kidney disease…
Preliminary Musings on PARADISE-MI (sacubitril-valsartan post MI)
Cardiologists have been happily prescribing angiotensin receptor neprilysin inhibitor, sacubitril-valsartan, for heart failure with reduced ejection (HFrEF) for a while now. And the drug was…
“Breakthrough” devices – to fast-track or not to fast-track
In the US, the FDA (Food and Drug Administration) approves new medical devices. The CMS (Centers for Medicare & Medicaid Services) decides whether to cover…
The First Truly Effective Weight Loss Drug Arrives
It looks like the first truly effective weight loss drug has arrived. Learn the basic facts about semaglutide and get perspectives from Milton Packer and Sanjay Kaul on what lies ahead.
Trials in Heart Failure with Preserved Ejection Fraction: An Interview with Steve Nissen and Milton Packer
Faiez Zannad moderates a fascinating discussion between Milton Packer and Steve Nissen about the PARAGON-HF trial in heart failure with preserved ejection fraction. Nissen was…
A Brand New Drug for Heart Failure with Reduced Ejection Fraction: An Interview with Javed Butler about Vericiguat
Faiez Zannad speaks to Javed Butler about the FDA approval of new drug, vericiguat, for heart failure with reduced ejection fraction, following the publication of…
Global Trials Summit 2021: An Interview with John McMurray
Faiez Zannad speaks to John McMurray about the Global Trials Summit being held virtually on 12th and 13th February 2021. Register here : https://global-trials-summit.hubilo.com/